TABLE 1.
Agents that inhibit neointima formation in rat vessels do not necessarily perturb intimal thickening in higher species or humans
NI denotes neointimal thickening.
| Drug | Species | Model or clinical setting | Effect on NI | Reference |
|---|---|---|---|---|
| Heparin | Human | Coronary artery stenting with heparin-coated stents (clinical) | No effect | (41) |
| Baboon | Aortoiliac bypass grafting with heparin-coated ePTFE graft | Inhibition | (42) | |
| Pig | Coronary artery restenosis | No effect | (43) | |
| Rat | Carotid artery restenosis | Inhibition | (43) | |
| E2F decoy | Human | Intraoperative ex vivo vein graft (clinical) | No effect | (44) |
| Rabbit | Jugular vein to carotid artery interposition vein graft | Inhibition | (6) | |
| Rat | Carotid artery restenosis (HVJ-liposomes) | Inhibition | (39) | |
| Carvedilol | Human | Restenosis after coronary stenting | No effect | (45) |
| Rat | Carotid artery restenosis | Inhibition | (46) | |
| Candesartan | Human | Restenosis after coronary stenting | No effect | (47) |
| Rat | Graft arteriosclerosis after rat aortic transplant | Inhibition | (48) | |
| Cilazapril | Human | Restenosis after coronary stenting | No effect | (49) |
| Rat | Carotid artery restenosis | Inhibition | (50) | |
| Rapamycin | Human | Restenosis after coronary stenting | Inhibition | (51–53) |
| Rat | Carotid artery mitogenesis | Inhibition | (54) | |
| Paclitaxel | Human | Restenosis after coronary stenting | Inhibition | (55) |
| Rat | Carotid artery restenosis | Inhibition | (56) |