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Superposition of catalytic site between TtHCS·Cu2+·HC complex and LiCMS·Zn2+·pyruvate·acetyl- CoA complex. The TtHCS·Cu2+·HC complex and the LiCMS·Zn2+·pyruvate·acetyl-CoA complex are shown as green and cyan sticks, respectively. Hydrogen bonds between ligand and proteins are shown as dashed lines. His-302* of LiCMS, corresponding to His-292* of TtHCS, is not seen due to disorder of the regions containing this residue in the LiCMS structure.
