Mapping of mutations conferring feedback resistance to ScHCSs on structure of TtHCS·Co2+·Lys complex. A dimer structure of the TtHCS·Co2+·Lys complex is shown. In a monomer, (β/α)8 TIM barrel domain, C-terminal small domain I, and C-terminal small domain II are shown in green, yellow, and purple, respectively. The adjacent subunit is in gray. Metal Co2+ is shown as pink spheres, and bound lysine is shown as magenta sticks.