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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2009 Dec 3;30(2):218–224. doi: 10.1161/ATVBAHA.109.199299

Figure 2. Streptozotocin-induced hyperglycemia increases NFAT-dependent transcriptional activity.

Figure 2

A. Blood glucose levels in NFAT-luc transgenic mice treated with STZ or vehicle. *P < 0.05 and ***P < 0.001 vs. vehicle. B. Correlation between luciferase activity (RLU μg-1) and blood glucose levels at day 16 (N=12). C. NFAT- luciferase activity in aortas treated as in A, measured at day 8, 12 and 16 after the first STZ injection, normalized to vehicle. Luciferase activity in vehicle mice did not differ between days 8, 12 and 16. N=12-16 for each time point. *P < 0.05 vs. vehicle. D. Luciferase activity in aortas from diabetic NFAT-luc/NFATc3+/+, NFAT-luc/NFATc3+/- and NFAT-luc/NFATc3-/- mice, measured at day 12 after the first STZ injection. Values are normalized to non-diabetic NFAT-luc/NFATc3+/+ vehicle (dotted line). N=6-9 mice in each group. *P < 0.05 vs. vehicle.