Table 1.
Demographic, clinical, and genetic characteristics of 1539 probable Alzheimer disease (AD) patients
| Probable AD subjects | ||||
|---|---|---|---|---|
| With at least one annual evaluation | Without annual evaluation | t Test/χ2 | p Value | |
| No of subjects | 943 | 596 | ||
| Mean (SD) age at study entry | 73.1 (8.7) | 74.2 (8.1) | 2.53 | 0.01 |
| Gender: women (%) | 635 (67) | 421 (71) | 1.84 | 0.17 |
| Mean (SD) education level (years) | 12.4 (2.9) | 11.7 (2.9) | −4.69 | <0.001 |
| Race: Caucasians (%) | 888 (94) | 546 (92) | 3.75 | 0.05 |
| Mean (SD) MMSE | 18.2 (5.4) | 15.0 (6.3) | −10.5 | <0.001 |
| Mean (SD) MDRS (n=1160) | 109.5 (19.5) | 102.3 (23.6) | −5.65 | <0.001 |
| Mean (SD) CDR | 1.2 (0.59) | 1.5 (0.78) | 9.39 | <0.001 |
| Mean (SD) BDRS for ADL | 5.2 (3.8) | 6.8 (4.6) | 7.25 | <0.001 |
| Mean (SD) NYU scale for parkinsonism | 9.7 (12.0) | 14.0 (12.9) | 6.16 | <0.001 |
| Mean (SD) HDRS | 6.1 (4.3) | 7.4 (5.3) | 4.70 | <0.001 |
| Mean (SD) HRS | 2.4 (1.7) | 2.7 (2.1) | 3.27 | 0.001 |
| Mean (SD) duration (years) of the disease* | 3.8 (2.3) | 4.4 (2.9) | 11.4 | 0.001 |
| APOE-4 allele (n=1067) (%) | 416 (58) | 201 (57) | 0.16 | 0.68 |
| Hypertension†(%) | 377 (40) | 227 (38) | 0.54 | 0.45 |
| Diabetes mellitus‡ (%) | 63 (7) | 47 (8) | 0.79 | 0.37 |
| Heart disease§ (%) | 132 (14) | 88 (11) | 2.16 | 0.14 |
*
From symptom onset to initial evaluation.
†
Told by doctor.
‡
Told by doctor and using hypoglycaemic agents.
§
History of congestive heart failure, angina, or coronary by pass grafting/coronary angioplasty.
BDRS for ADL, Blessed Dementia Rating Scale for Activities of Daily Living; CDR, Clinical Dementia Rating; HDRS, Hamilton Depression Rating Scale; HRS, Hachinski Rating Scale; MDRS, Mattis Dementia Rating Scale; MMSE, Mini-Mental State examination; NYU, New York University.