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. 2010 Jan 27;91(3):662–671. doi: 10.3945/ajcn.2009.28750

TABLE 4.

Estimates of genetic (A), common environmental (C), and individual specific environmental (E) effects on insulin sensitivity (IS)–related measures and adiposity measures in adolescents aged 13–20 y by using univariate model fitting1

Intrapair correlations
 Parameter estimates
MZ DZ A (95% CI) C (95% CI) E (95%CI) χ2 P value AIC2
Male
 IS-related measures
  QUICKI 0.58 0.10 0.50 (0.37, 0.61) — 0.50 (0.39, 0.63) 0.00 — −2.00
 HOMA-IR3 0.62 0.13 0.57 (0.45, 0.66) — 0.43 (0.34, 0.55) 0.00 — −2.00
 FSI3 0.63 0.11 0.58 (0.46, 0.68) — 0.42 (0.32, 0.54) 0.00 — −2.00
 Adiposity measures
  BMI 0.91 0.58 0.86 (0.82, 0.89) — 0.14 (0.11, 0.18) 0.00 — −2.00
  WC 0.87 0.56 0.77 (0.70, 0.82) — 0.23 (0.18, 0.30) 0.28 0.599 −1.73
  %BF 0.87 0.48 0.87 (0.82, 0.90) — 0.13 (0.10, 0.18) 0.29 0.589 −1.71
Female
 IS-related measures
  QUICKI 0.53 0.30 0.55 (0.44–0.64) — 0.45 (0.36, 0.56) 0.29 0.590 −1.71
  HOMA-IR3 0.54 0.30 0.56 (0.45–0.65) — 0.44 (0.35, 0.55) 0.24 0.622 −1.76
  FSI3 0.55 0.30 0.57 (0.47–0.66) — 0.43 (0.34, 0.53) 0.21 0.646 −1.79
 Adiposity measures
  BMI 0.89 0.57 0.48 (0.24, 0.81) 0.35 (0.02, 0.58) 0.17 (0.13, 0.22) — — —
  WC 0.83 0.52 0.78 (0.72, 0.83) — 0.22 (0.17, 0.28) 3.04 0.081 1.04
  %BF 0.86 0.49 0.81 (0.76, 0.86) — 0.19 (0.14, 0.24) 0.70 0.402 −1.30
1

QUICKI, QUantitative Insulin-sensitivity ChecK Index; HOMA-IR, homeostasis model assessment of insulin resistance; FSI, fasting serum insulin; WC, waist circumference; %BF, percentage body fat; AIC, Akaike's Information Criterion; MZ, monozygotic; DZ, dizygotic. Age, Tanner stage, and physical activity were adjusted as covariates in the structural equation modelings.

2

Chi-square and AIC were used to compare the goodness-of-fit of the models (AE and CE models) with the saturated fat model (ACE model). Only the estimates from the best-fit models are presented.

3

Natural log transformed.