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Distribution of ciprofloxacin MICs in S. pneumoniae isolates with a parC only amino acid substitutions. The figure shows that pneumococcal isolates with substitution at either position 79 or 83 of parC have four-fold increased ciprofloxacin MIC compared to isolates with no mutations in parC. On the other hand, substitution at position 137 of parC does not appear to increase ciprofloxacin MIC.
