Table 1.

Summary of Randomized LMWH Trauma Studies which Report Bleeding Complications

Study	Design	Type of LMWH	No. Patients	Non-Fatal Bleeding	Fatal Bleeding
Geerts et al. 1996[10]	Randomized
	UH 5,000 U SC BID vs. LMWH 30 mg SC BID	Enoxaparin	171*	5 (2.9%)	0
	Multi-system trauma & ISS ≥ 9
Knudson et al. 1996[20]	Randomized
	LMWH 30 mg SC BID vs. SCD or AVI bilaterally	Enoxaparin	120	6 (5%)	0
	Multi-system trauma & AIS ≥ 3 with ISS > 10
Ginzburg et al. 2003[19]	Randomized
	LMWH 30 mg BID vs. IPC bilaterally	Enoxaparin	218	13 (6%)	0
	Multi-system trauma & ISS ≥ 9
	Multi-system Trauma Bleeding Risk			24/509 (4.7%)	0%
Green et al. 1990[17]	Randomized
	UH 5,000 U SC TID vs. LMWH 3500 U SC QD	Logiparin	20	0	0
	Spinal cord trauma & complete motor paraylsis
Spinal Cord Injury Thromboprophylaxis Investigators 2003[18]	Randomized
	UH 5,000 U SC TID + IPC vs. LMWH 30 mg SC BID	Enoxaparin	230	6 (2.6%)	0
	Spinal cord trauma
Kurtoglu et al. 2004[13]	Randomized
	LMWH 40 mg QD vs. IPC bilaterally	Enoxaparin	60	2 (3.3%)	0
	Head and Spinal Trauma
	Spinal Cord Trauma Bleeding Risk			8/310 (2.6%)	0%
	Combined Total Bleeding Risk			32/819 (3.9%)	0%

* 344 patients randomized and assessed for bleeding whereas only 265 patients had venograms adequate for DVT analysis ISS, Injury Severity Score; SCD, Sequential Compression Device; IPC, Intermittent Pneumatic Compression