Table 5. Interaction analysis of TIMELESS variants with all other genotyped circadian genes.

Chr1	SNP1	Gene1	Chr2	SNP2	Gene2	P-values	OR	Gender	Phenotype
12	rs2291739	TIMELESS	17	rs3027188	PER1	0.019	0.51	Females	D+FAT+
12	rs2291739	TIMELESS	17	rs2253820	PER1	0.046	0.59	Females	D+FAT+
12	rs2291739	TIMELESS	12	rs4964052	ARNTL2	0.049	0.71	Females	D+FAT+
12	rs2291739	TIMELESS	12	rs922270	ARNTL2	0.05	1.65	Females	D+FAT+
12	rs2291738	TIMELESS	2	rs1811399	NPAS2	0.022	1.59	Females	D+FAT+
12	rs2291738	TIMELESS	22	rs7289981	CSNK1E	0.042	0.57	Females	D+FAT+
12	rs7486220	TIMELESS	17	rs3027188	PER1	0.008	0.45	Females	D+FAT+
12	rs7486220	TIMELESS	17	rs2253820	PER1	0.044	0.57	Females	D+FAT+
12	rs1082214	TIMELESS	11	rs2290036	ARNTL	0.028	0.09	Females	D+FAT+
12	rs1082214	TIMELESS	11	rs4757151	ARNTL	0.037	0.44	Females	D+FAT+
12	rs1082214	TIMELESS	4	rs10462028	CLOCK	0.031	2.19	Females	D+FAT+
12	rs2291739	TIMELESS	15	rs2290430	RORA	0.005	10.1	Males	D+EMA+
12	rs2291739	TIMELESS	11	rs1868049	ARNTL	0.0006	4.36	Males	D+EMA+
12	rs2291739	TIMELESS	11	rs4757151	ARNTL	0.002	2.31	Males	D+EMA+
12	rs2291739	TIMELESS	11	rs3897902	ARNTL	0.003	4.18	Males	D+EMA+
12	rs2291739	TIMELESS	11	rs3816358	ARNTL	0.019	0.40	Males	D+EMA+
12	rs2291739	TIMELESS	11	rs969485	ARNTL	0.043	2.08	Males	D+EMA+
12	rs2291739	TIMELESS	12	rs922270	ARNTL2	0.027	0.21	Males	D+EMA+
12	rs2291738	TIMELESS	11	rs4757151	ARNTL	0.004	2.23	Males	D+EMA+
12	rs2291738	TIMELESS	11	rs1868049	ARNTL	0.005	3.16	Males	D+EMA+
12	rs2291738	TIMELESS	11	rs3897902	ARNTL	0.006	3.76	Males	D+EMA+
12	rs2291738	TIMELESS	11	rs3816358	ARNTL	0.041	0.46	Males	D+EMA+
12	rs2291738	TIMELESS	17	rs2289591	PER1	0.010	2.72	Males	D+EMA+
12	rs2291738	TIMELESS	15	rs2290430	RORA	0.017	6.53	Males	D+EMA+
12	rs2291738	TIMELESS	19	rs3745733	DBP	0.031	2.25	Males	D+EMA+
12	rs2291738	TIMELESS	1	rs3753503	PER3	0.039	8.42	Males	D+EMA+
12	rs2291738	TIMELESS	12	rs3809237	CRY1	0.045	1.75	Males	D+EMA+
12	rs7486220	TIMELESS	15	rs4774370	RORA	0.003	3.12	Males	D+EMA+
12	rs7486220	TIMELESS	1	rs3753503	PER3	0.031	5.18	Males	D+EMA+
12	rs7486220	TIMELESS	15	rs16943429	RORA	0.038	2.16	Males	D+EMA+
12	rs1082214	TIMELESS	17	rs2269457	NR1D1	0.003	3.97	Males	D+EMA+
12	rs1082214	TIMELESS	15	rs2028122	RORA	0.006	0.20	Males	D+EMA+
12	rs1082214	TIMELESS	15	rs3759785	TIPIN	0.020	11.56	Males	D+EMA+
12	rs1082214	TIMELESS	15	rs2063690	TIPIN	0.041	3.80	Males	D+EMA+

Chr: Chromosomes.

P-values and Odds ratios (OR) were generated using the logistic regression model. None of the P-values remained significant (P<0.05) when considering the number of tests performed (408 in both genders).

D+FAT+, depressed patients with fatigue.

D+EMA+, depressed patients with early morning awakening.