Table 1. Genetic variation between mother and infant in epidemiologically linked transmission pairs.
Patient ID | Subject | Months post-birtha | No of sequences | No of unique haplotypes | Diversity (%)b | dN/dSc | Median length (range) of V1-V5 | Median PNGS (range) of V1-V5 |
1449 | Mother Infant | N/A 2 | 37 26 | 37 21 | 6.13±2.72 0.48±0.15 | 0.77 0.71 | 337 (327–340) 330 | 23 (19–27) 21 (18–21) |
2669 | Mother Infant | N/A 2 | 32 30 | 32 29 | 3.16±0.90 0.71±0.29 | 0.83 0.54 | 340 (331–347) 339 (335–339) | 26 (22–29) 25 (23–25) |
2873 | Mother Infant | N/A 2 | 31 29 | 30 26 | 5.25±2.25 0.60±0.28 | 0.81 0.91 | 352 (334–356) 356 | 26 (23–28) 28 (27–29) |
2617 | Mother Infant | N/A 2 | 27 27 | 26 27 | 0.77±0.23 0.63±0.32 | 0.59 0.52 | 338 (336–341) 336 | 24 (23–25) 23 (22–24) |
1984 | Mother Infant | N/A 4 | 30 25 | 29 25 | 2.53±1.4 1.11±0.43 | 0.88 0.89 | 339 (336–345) 343 | 24 (22–26) 21 (19–22) |
1084 | Mother Infant | N/A 6 | 41 25 | 27 25 | 5.35±3.1 1.38±0.47 | 0.98 0.62 | 333 (326–334) 319 (319–328) | 23 (19–26) 21 (19–23) |
Maternal samples at delivery were defined as baseline and infant baseline samples were referred to the first postpartum HIV-1 PCR positive time point as indicated in months.
Standard deviations for genetic diversity are indicated.
dN/dS calculated after screening for recombination.
N/A means that this category is not applicable to maternal subjects.