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. 2010 Feb 18;5(2):e9209. doi: 10.1371/journal.pone.0009209

Table 1. vTK/GCV induced liver failure in FVB/N mice.

Animal ID Gender (M/F) vTK Status GCV Dose (mg/kg) Health Status Liver Color ALT (IU/L) T0 Tf AST (IU/L) T0 Tf
3.2 M − 0 +++ Red 53 49 88 94
3.18 M − 10 +++ Red 55 51 75 84
3.19 M − 10 +++ Red 54 52 99 79
3.12 F − 25 +++ Red 48 44 100 88
3.14 F − 25 +++ Red 45 49 102 101
3.1 F − 50 +++ Red 51 48 79 87
3.3 M + 0 +++ Red 48 52 81 101
3.21 M + 10 ++ Pale Red 51 53 91 83
3.11 F + 25 + Pale 53 230 88 896
3.13 M + 25 + Pale 49 247 106 1036
3.9 M + 50 + Very Pale 48 304 73 1211
3.10 F + 50 + Very Pale 51 309 89 1214

GCV was administered to vTK+ and vTK-FVB/N mice for 5 days. Health status ranged from excellent (+++), to poor (++), to critical. ALT and AST levels were determined for blood draws obtained at 1 hour prior to (T0) and at the end of (Tf) the dosing period. Livers ranged from healthy/normal (red), to very pale at the end of the study.