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. Author manuscript; available in PMC: 2010 Dec 7.
Published in final edited form as: Cell Stem Cell. 2009 Dec 4;5(6):624–633. doi: 10.1016/j.stem.2009.10.003

Figure 6. Effect of FK506 on Dendritic Maturation of Adult-Born GCs.

Figure 6

(A, B) Photomicrographs of dendrites (A) and spines (B) of 28-day-old adult-born GCs in 2–3-month-old NTG and hAPP-J20 mice treated with vehicle or FK506 (5 mg/kg) from 14–27 dpi. Scale bars: 20 µm (A), or 3 µm (B).

(C) Quantification of dendritic length and spine density of 28-day-old adult-born GCs in 2–3-month-old NTG and hAPP-J20 mice treated with vehicle or with 5 mg/kg of FK506. A two-way ANOVA analysis identified a significant genotype effect on both dendritic length (F(1,167) = 19.22, P < 0.0001) and spine density (F(1,104) = 4.338, P = 0.0397), a significant main effect of FK506 treatment on both dendritic length (F(1,167) = 17.08, P < 0.0001) and spine density (F(1,104) = 6.033, P = 0.0157), and a significant genotype × FK506 treatment interaction for both dendritic length (F(1,167) = 9.664, P = 0.0022) and spine density (F(1,104) = 11.27, P = 0.0011). ***, P < 0.001, Bonferroni posthoc test. Values are means ± SEM.