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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: J Inorg Biochem. 2010 Jan 4;104(4):485–488. doi: 10.1016/j.jinorgbio.2009.12.017

Figure 3.

Figure 3

Inhibition of P450 2B6 activity by synthetic peptides. The incubations of the peptides with the P450 reductase and the subsequent determination of P450 2B6 activity were performed as described in the text. The peptides used were: (●) DFGMGKR, (■) Scrambled-GRMKGFD and (▲) Nonsense-VFCMGAR. The control activity refers to the activity observed in the absence of any synthetic peptide. Error bars represent the standard deviations. Data points representing incubation with the DFGMGKR peptide were statistically significant when compared to the corresponding scrambled-GRMKGFD peptide values. Data are labeled with one asterisk (*) if p<0.05 and two asterisks (**) if p<0.01. All of the DFGMGKR peptide data were statistically significant (p<0.01) when compared to the nonsense-VFCMGAR peptide. Significance was determined by performing one-tailed, unpaired t-tests using GraphPad Prism version 5.01 for Windows (GraphPad Software, San Diego, California).