RTX-A inhibits basal AP-1 (a), NF-κB (c) or p53 (e) – dependent transcriptional activity in JB6 Cl41 mouse epidermal cells. The effects of RTX-A on the viability of JB6 Cl41 AP-1 (b), NF-κB (d), or p53 (f) cells. Data are represented as means ± S.D. of six samples from two independent experiments. The asterisk (*) indicates a significant decrease (p < 0.05) in AP-1 (b), NF-κB (d), or p53 (f) activation, or in JB6 Cl 41 cells viability.