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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Semin Immunol. 2010 Jan 6;22(1):25–33. doi: 10.1016/j.smim.2009.12.002

Figure 3.

Figure 3

Genomic organization of two VLR-like genes in the zebrafish. The two VLR-like genes separated by 4.4 kb in the zebrafish genome assembly (Accession No. BX569794). Both genes contain all core VLR components identically juxtaposed as in cyclostome mVLRs. However, these genes contain comparatively more LRR cassettes than the average VLR molecule in cyclostomes and lack the ability to undergo genomic diversification. The exact phylogenetic relationship to cyclostome VLRs is unclear, though there is a distinct possibility that they are evolutionarily related at least on the basis of their similar genomic organizations. The functionality of these molecules is largely unknown. Color coding of structural features is presented in the inset and is identical to that in Figure 2. The illustration is not drawn to scale.