Figure 1.

A schematic representation of mast cell components and products which may mediate interactions with T-cells. The intermediary molecules are either secreted (e.g. cytokines, chemokines, leukotrienes, histamine) or membrane-bound (e.g. MHC, costimultory/coinhibitory molecules, adhesion molecules). It is anticipated that different inflammatory settings will result in varying expression of these components thus leading to the versatile role of MC in disease models.