Table 1.

Nine cancer-related genes identified from HepG2 cDNA library screening.

Designation	Insert size (kb)	Identity (access no.)	cDNA size (kb)	Functional significance and cancer association
EP-HCC-1	0.65	Translation initiation factor, hu-sui1 (BC008710)	1.32	Associated with apoptosis; related to HCC [18,19]
EP-HCC-5	0.88	Homo sapiens interferon gamma receptor 2 (BC003264)	2.77	Associated with the inhibition of tumor cell growth [20]
EP-HCC-6	0.96	Homo sapiens ferritin (BC016354)	0.90	Regulator of cellular differentiation. Associated with increased risk of liver and breast cancers [21,22]
EP-HCC-7	0.68	Serine proteinase inhibitor; pigment epithelium derived factor, PEDF (BC000522)	1.45	Associated with apoptosis; plays a role in the antiangiogenic properties of HCC [23,24]
EP-HCC-8	0.89	Antitrypsin-alpha 1-AT (NM_001002235)	1.59	Serine proteinase inhibitor, Associated with increased risk of cirrhosis and primary liver cancer [25]
EP-HCC-9	0.76	TAP2, a transporter associated with antigen processing (AB073779)	2.11	Plays a key role in the adaptive immune response; TAP2 functions as a tumor suppressor gene; related to HCC [26]
EP-HCC-10	0.56	Homo sapiens upstream transcription factor 2-USF2 (BC042655)	2.80	Antiproliferative activities and regulation of several genes involved in tumorigenesis [27]
EP-HCC-12	0.89	Homo sapiens fibronectin 1-FN1 (BC016875)	1.51	Associated with cell proliferation and apoptosis, have a role in the pathogenesis of papillary thyroid carcinoma [28,29]
EP-HCC-13	0.79	v-Ral simian leukemia viral oncogene homolog A (Ras related)-RalA (BC039858)	2.77	Oncogene; it may play a role in cell motility and tumor metastasis [30–33]