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. Author manuscript; available in PMC: 2011 Mar 3.
Published in final edited form as: J Control Release. 2009 Oct 17;142(2):187–195. doi: 10.1016/j.jconrel.2009.10.013

Figure 2.

Figure 2

Stabilization of influenza vaccine coatings. (A) Effects of various carbohydrates on retaining the HA activity of inactivated influenza virus during drying. Influenza vaccines in coating solution containing various carbohydrates were dried on pieces of stainless steel mimicking microneedles and then reconstituted to determine the HA activity. All carbohydrates were added at a concentration of 15% (w/v). Data are presented as the percent HA activity compared to the same amount of unprocessed inactivated whole virus in PBS solution without drying (n=4, *p <0.05 for pair wise comparisons between the “coating solution + trehalose” formulation and all other formulations). (B) Particle-size distribution determined by dynamic light scattering in coating solution (control) or reconstituted microneedle coatings prepared using coating solution (CS) with or without 15% trehalose.