Table 4.
Summary of results of 12-month longitudinal atrophy estimation experiments using nine DBM configurations summarized in Equation (6). See caption to Table 2 for the meaning of the rows and columns. For each cell, the mean atrophy and standard deviation are given in the MCI and control groups, as well as the p-value of the MCI-control group comparison, and the sample size needed to detect 25% reduction in MCI atrophy relative to control atrophy with 80% power and significance level 0.05. Lower sample size indicates more powerful atrophy estimation.
| RIGID |
|||||
|---|---|---|---|---|---|
| BL | HW | FU | |||
| NON-RIGID | BL | μ MCI: | −0.07% | 2.31% | 3.56% |
| σ MCI: | 2.50% | 1.92% | 1.84% | ||
| μ CTL: | −1.88% | 0.91% | 2.58% | ||
| σ CTL: | 1.64% | 1.13% | 1.55% | ||
| p -value: | 4.52E-06 | 1.76E-06 | 1.89E-03 | ||
| N: | 482 | 474 | 892 | ||
| CI 0.9 (N): | 263–1230 | 265–1183 | 386–4287 | ||
| HW | μ MCI: | 0.36% | 2.04% | 4.78% | |
| σ MCI: | 2.55% | 1.91% | 1.85% | ||
| μ CTL: | −1.57% | 0.69% | 3.50% | ||
| σ CTL: | 1.58% | 1.10% | 1.36% | ||
| p -value: | 1.06E-06 | 3.18E-06 | 2.1E-05 | ||
| N: | 438 | 508 | 519 | ||
| CI 0.9 (N): | 240–1146 | 283–1280 | 272–1459 | ||
| FU | μ MCI: | 0.93% | 1.69% | 5.80% | |
| σ MCI: | 2.35% | 1.91% | 1.80% | ||
| μ CTL: | −0.96% | 0.34% | 4.42% | ||
| σ CTL: | 1.48% | 1.11% | 1.19% | ||
| p -value: | 3.05E-07 | 2.93E-06 | 1.32E-06 | ||
| N: | 391 | 499 | 426 | ||
| CI 0.9 (N): | 218–1025 | 279–1214 | 232–1047 | ||