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. Author manuscript; available in PMC: 2011 Apr 15.
Published in final edited form as: Biochem Pharmacol. 2009 Dec 16;79(8):1125–1133. doi: 10.1016/j.bcp.2009.12.010

Fig. 7. Proposed mechanism on how β-tubulin plays a role in the AhR signaling.

Fig. 7

By interacting with Arnt in the cytoplasm, β-tubulin controls the Arnt content in the nucleus. Increased cytoplasmic β-tubulin content reduces the nuclear Arnt content, causing a reduction of the amount of the AhR/Arnt heterodimer formation upon ligand activation. Activation of the AhR-dependent gene transcription is compromised when the cytoplasmic β4-tubulin content increases.