Table 1.

Major hemodynamic and cardiac contractile function variables in 2 MO and 14 MO WT and KO mice after burn complicated by sepsis

	2 MO				14 MO
	Sham		B + S		Sham		B + S
	WT	KO	WT	KO	WT	KO	WT	KO
Steady-State
HR	557 ± 8	562 ± 8	495 ± 7^*	539 ± 7^†	556 ± 10	564 ± 12	439 ± 21^*^#	378 ± 20^*^#^†
MAP	84 ± 2	88 ± 3	82 ± 3	84 ± 3	81 ± 4	87 ± 4	63 ± 3^*^#	50 ± 4^*^#^†
CO	9.3 ± 0.3	9.6 ± 0.6	4.9 ± 0.3^*	7.4 ± 0.3^*^†	8.5 ± 0.6	8.4 ± 0.3	4.0 ± 0.3^*^#	3.5 ± 0.4^*^#^†
SVR	9.2 ± 0.3	9.6 ± 0.6	17.5 ± 1.0^*	11.6 ± 0.6^*^†	9.9 ± 0.6	10.1 ± 0.6	17.2 ± 1.6^*	24.5 ± 4.9^*^#
IVC Occlusion
ESPVR	20.7 ± 2.8	22.6 ± 3.0	4.6 ± 0.8^*	6.9 ± 0.8^*^†	17.5 ± 3.0	15.5 ± 2.6	2.8 ± 0.3^*^#	1.9 ± 0.3^*^#^†
PRSW	104 ± 5	108 ± 5	37 ± 2^*	77 ± 4^*^†	92 ± 7	89 ± 9	30 ± 3^*^#	22 ± 2^*^#^†
E_max	39.7 ± 2.1	41.3 ± 2.3	18.0 ± 1.5^*	26.8 ± 2.9^*^†	35.4 ± 2.4	34.8 ± 1.8	13.7 ± 1.5^*^#	8.9 ± 0.9^*^#^†

HR: heart rate (beats per minute); MAP: mean arterial pressure (mmHg); CO: cardiac output (mL/min); SVR: systemic vascular resistance (mmHg/mL/min); ESPVR: end-systolic pressure volume relationship (mmHg/μL); PRSW: preload-recruitable stroke work (mmHg·μL); E_max: maximum elastance (mmHg/−L). Data are expressed as mean ± SEM.

p < 0.05 between sham and B+S

p < 0.05 between 2 MO and 14 MO mice, and

^†

p < 0.05 between WT and KO.