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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Neuroimage. 2009 Dec 24;50(2):416–427. doi: 10.1016/j.neuroimage.2009.12.070

Figure 2.

Figure 2

Amyloid deposits are readily apparent in T2- and T2* weighted (GRASS) images. A. The largest plaques can be seen with all 3 sequences (arrows), although the best sensitivity is provided by T2*-weighted (GRASS) images and the best specificity by the MEFIC-processed T2-weighted images. All images shown here were taken from a DBL transgenic mouse 4 mo after APP induction; the top row displays high-resolution (21.5 μm) T1- and T2*-weighted (GRASS) images and the bottom row shows the first two echoes from a multiecho MEFIC processed T2-weighted image (a: 7 ms TE, b: 14 ms TE). While plaques can be seen in all images, the second echo (T2b) and the T2*-weighted images are better at discriminating smaller plaques. B. H istological staining confirms that DBL transgenic mice have a mild amyloid burden throughout the cortex and hippocampus by 4 mo of age. The lower panel shows the boxed region of the upper section at a higher magnification. Histological sections shown in B and MR slices shown in A are taken from different mice so no alignment of deposits with hypointensities is shown.