Male C57Bl/6 mice were exposed to high fat lard diet (HFL) and control diet (C-HFL) for 19 weeks, and the effects of diet on brain levels of the cytokine TNFα and IL-6, the chemokine MCP-1, and the growth factor BDNF were evaluated by ELISA as described in Methods. Data are means and SEM, with 8–10 individual mice per group, and statistical analyses (two-tailed, unpaired t-tests) indicated a significant effect of HFL on TNFα (p < 0.01), IL-6 (p < 0.01), MCP-1 (p < 0.001), and BDNF (p < 0.05) levels in the cortex.