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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Exp Eye Res. 2009 Nov 25;90(3):376–381. doi: 10.1016/j.exer.2009.11.003

Figure 2. PDGF-C is secreted in a latent state.

Figure 2

PDGF-C is secreted in a biologically inactive (latent) form. Proteolytic cleavage of the CUB domain permits the core domain to bind and activate PDGFRs. The diagram shows an autocrine relationship between cells that produce and respond to PDGF; this appears to be the case for mesenchymal cells (Fredriksson, L. et al., 2004b; Gilbertson, D.G. et al., 2001). PDGF-C is also likely to activate cells in a paracrine manner.