Table 3.
Number of Subjects (per treatment group or per disease/phenotype) Needed to Detect Listed Effect Size with ≥80% Power (2-sided α=0.05) Based on a Two-Sample t-Test.
| Response | CV inter (%) | Effect size (%) demonstrable | N per group required |
|---|---|---|---|
| Compliance Pr50 mmHg |
22.8 | 25 | 15 |
| 30 | 11 | ||
| 35 | 8 | ||
| Fasting Tone, ml | 30.8 | 25 | 25 |
| 30 | 18 | ||
| 35 | 14 | ||
| First 30 minute postprandial change in tone vs fasting, ml |
59.1 | 25 | 89 |
| 30 | 62 | ||
| 35 | 46 | ||
| Pain Threshold, mmHg |
31 | 25 | 26 |
| 30 | 18 | ||
| 35 | 14 | ||
| Gas sensation rating with 36 mmHg distension |
41.9 | 25 | 46 |
| 30 | 32 | ||
| 35 | 24 | ||
| Pain sensation rating with 36 mmHg distension |
56.3 | 25 | 81 |
| 30 | 57 | ||
| 35 | 42 |