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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2009 Dec 1;3(1):88–95. doi: 10.1161/CIRCEP.109.886275

Figure 3.

Figure 3

Synergistic effects of acute ranolazine and chronic amiodarone to significantly increase diastolic threshold of excitation (DTE) in coronary-perfused right atrial preparations. n=6–12. * p<0.001 vs control; † p<0.01 vs chronic Amiodarone alone and vs ranolazine. Control n=9 recordings (8 PM and 1 CT) from 8 dogs; ranolazine n=9 recordings(8 PM and 1 CT) from 8 dogs; chronic amiodarone n =12 recordings (7 PM and 5 CT) from 8 dogs; chronic amiodarone+ranolazine n=6 recordings (4 PM and 2 CT) from 4 dogs.