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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2009 Dec 1;3(1):88–95. doi: 10.1161/CIRCEP.109.886275

Figure 4.

Figure 4

Potent depression of excitability induced by a combination of chronic amiodarone and acute ranolazine (5 μM) leading to activation failure at rapid rates in coronary-perfused right atria. A: Failure of 1:1 activation at a pacing cycle length (CL) of 350 ms. B: Failure of 1:1 activation at a CL of 200 ms in the presence of acetylcholine (B). C: Increase in CL needed to maintain 1:1 activation (see Table 1 for actual numbers). Ran = Ranolazine (n=10); Amio = Chronic amiodarone (n=8). Ran + Amio (n=4). Ran n=10 dogs; Amio n =8 dogs; Amio+Ran n=4 dogs.