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Rate-dependence of action potential and conduction characteristics in LV wedge preparation isolated from chronic amiodarone-treated dog in the absence and presence of acute ranolazine (5 and 10 uM). Each panel shows a pseudo-ECG (top trace) and action potentials recorded from the M cell region. 1:1 activation persisted following a decrease in basic cycle length (BCL) from 2000 to 1000 and 300 ms.
