. Author manuscript; available in PMC: 2011 Feb 1.

Published in final edited form as: Circ Arrhythm Electrophysiol. 2009 Dec 1;3(1):88–95. doi: 10.1161/CIRCEP.109.886275

Table 1.

Shortest S1-S1 permitting 1:1 activation under control conditions, following chronic amiodarone, ranolazine and the combination of chronic amiodarone and acute ranolazine.

	Shortest S₁-S₁ permitting 1:1 activation (ms)
		+ Acetylcholine (0.5 μM)
Control (n= 11)	129 ± 8	71 ± 12
Chronic Amiodarone (n= 8)	222 ± 39^*	136 ± 22^*
Ranolazine (5 μM) (n= 10)	227 ± 38^*	94 ± 31^*
Chronic Amiodarone + Ranolazine (5 μM) (n= 4)	325 ± 34^*^†	205 ± 34^*^†

p<0.05 vs. respective controls: chronic Amiodarone + Ranolazine vs. chronic Amiodarone, Ranolazine (5 μM) vs. control and chronic Amiodarone vs. control

^†

p<0.05 vs. Ranolazine (5 μM), chronic Amiodarone and control