Table 2.
Electrode implantation and PBR densities at eight weeks after surgery
| Control | Electrode | Electrode vs. Control | |||
|---|---|---|---|---|---|
| Brain region | mean | ± SE | mean | ±SE | % change |
| CA1 | 8.2 | ± 0.4 | 8.0 | ± 0.3 | −2 |
| CA3 | 8.2 | ± 0.4 | 8.2 | ± 0.3 | 0 |
| DG | 12.0 | ± 0.4 | 12.5 | ± 0.4 | 4 |
| DLPFC | 10.2 | ± 0.4 | 10.8 | ± 0.5 | 7 |
| Ent Cx | 14.9 | ± 0.7 | 16.5 | ± 0.6# | 11 |
| Frontal Cx | 10.3 | ± 0.4 | 16.1 | ± 1.2** | 59 |
| Insular Cx | 9.8 | ± 0.3 | 10.9 | ± 0.3* | 10 |
| LDVL | 6.7 | ± 0.4 | 7.1 | ± 0.4 | 6 |
| mPFC | 9.2 | ± 0.6 | 11.3 | ± 0.9* | 23 |
| Occipital Cx | 9.5 | ± 0.3 | 9.5 | ± 0.2 | 0 |
| Parietal Cx | 9.9 | ± 0.2 | 11.0 | ± 0.3** | 11 |
| PRh Cx | 12.7 | ± 0.8 | 11.3 | ± 0.6 | −11 |
| SN | 8.7 | ± 0.5 | 10.5 | ± 0.5** | 21 |
| Striatum | 7.9 | ± 0.2 | 10.2 | ± 0.3** | 29 |
| Subiculum | 10.5 | ± 0.4 | 10.2 | ± 0.3 | −3 |
| Temporal Cx | 9.3 | ± 0.3 | 9.2 | ± 0.5 | 0 |
| vHipp | 10.2 | ± 0.4 | 9.7 | ± 0.5 | −4 |
| VPM | 6.3 | ± 0.3 | 7.4 | ± 0.3* | 18 |
| VPSI | 5.4 | ± 0.3 | 6.3 | ± 0.4# | 17 |
Animals were killed eight weeks after bilateral implantation of concentric electrodes. Values represent specifically bound radioactivity in nCi/mg from 20 control hemispheres (N=11 intact and 9 sham operated hemispheres) and 18 implanted hemispheres with 8–20 measurements/region. CA, cornu ammoni; Cx, cortex; DG, dentate gyrus; DLPFC, dorsolateral prefrontal cortex; Ent, Entorhinal; LDVL, laterodorsal thalamic nucleus-ventrolateral part; mPFC, medial prefrontal cortex; PRh, perirhinal; SN, substantia nigra; vHipp, ventral hippocampus; VPM, ventral postermedial thalamic nucleus; VPSI, ventral pallidum/substantia innominata.
p< 0.05,
p<0.01,
p < 0.1electrode vs. control, posthoc analysis following two way ANOVA (by region X treatment).