TABLE 2.
Baseline characteristics of participants of 21 unique prospective epidemiologic studies of saturated fat intake and risk of coronary heart disease (CHD) or stroke1
| Study | No. of subjects | Age | Sex | Country of residence | Smoker | Disease outcome | Method of diagnosis |
| y | % | ||||||
| CHD | |||||||
| Shekelle et al, 1981 (17) | 1900 | 40–55 | Male | USA | NR | Fatal CHD | DC |
| McGee et al, 1984 (9)2 | 8006 | 45–68 | Male | USA | NR | Total CHD | MR and DC |
| Kushi et al,1985 (13) | 1001 | 30–69 | Male | USA | NR | Fatal CHD | DC |
| Posner et al, 1991 (16) | 813 | 45–65 | Male | USA | 41.6 | Total CHD | MR |
| Fehily et al, 1993 (28) | 512 | 45–59 | Male | UK | NR | Total CHD | DC |
| Goldbourt et al, 1993 (35)2 | 97673 | ≥40 | Male | Israel | NR | Fatal CHD | MR and DC |
| Ascherio et al, 1996 (4) | 38,463 | 40–75 | Male | USA | 9.5 | Total CHD | MR and DC |
| Esrey et al, 1996 (6) | 4546 | 30–79 | Both | Canada | 33.9 | Fatal CHD | MR |
| Mann et al, 1997 (32) | 10,802 | 16–79 | Both | UK | 19.5 | Fatal CHD | MR |
| Pietinen et al, 1997 (15) | 21,930 | 50–69 | Male | Finland | 100 | Total CHD | MR and DC |
| Boniface and Tefft, 2002 (5) | 2676 | 40–75 | Both | UK | NR | Total CHD | DC |
| Jakobsen et al, 2004 (8) | 3686 | 30–71 | Both | Denmark | NR | Total CHD | MR |
| Leosdottir et al, 2007 (14)2 | 28,098 | 45–73 | Both | Sweden | 29.5 | Total CHD | DC |
| Oh et al, 2005 (33) | 78,778 | 30–55 | Female | USA | NR | Total CHD | MR and DC |
| Tucker et al, 2005 (18) | 2663 | 34–80 | Male | USA | 21.8 | Fatal CHD | MR and DC |
| Xu et al, 2006 (10) | 2938 | 47–79 | Both | USA | 29.7 | Total CHD | MR |
| Stroke | |||||||
| McGee et al, 1984 (9)2 | 8006 | 45–68 | Male | USA | NR | Total stroke | MR and DC |
| Goldbourt et al, 1993 (35)2 | 97673 | ≥40 | Male | Israel | NR | Fatal stroke | MR and DC |
| Gillman et al, 1997 (11) | 832 | 45–65 | Male | USA | NR | Ischemic stroke | MR |
| Iso et al, 2001 (31) | 85,764 | 34–59 | Female | USA | NR | Hemorrhagic stroke | MR and DC |
| He et al, 2003 (29) | 38,4633 | 40–75 | Male | USA | 9.5 | Total stroke | MR and DC |
| Iso et al, 2003 (30) | 4775 | 40–69 | Both | Japan | 13.5 | Hemorrhagic stroke | MR and DC |
| Sauvaget et al, 2004 (34) | 3731 | 35–89 | Both | Japan | 26–35 | Ischemic stroke | DC |
| Leosdottir et al, 2007 (14)2 | 28,098 | 45–73 | Both | Sweden | 29.5 | Ischemic stroke | DC |
1
NR, not reported; MR, medical records; DC, death certificate.
2
These studies provided both CHD and stroke outcome data.
3
These numbers, as provided by the respective investigators, differ from those used in the original publications.