(a) Normalized IL-6 CLSM intraparticle intensity profiles at 2hr, 5hr, and 18hr incubation times with CytoSorb beads. Intensity at each pixel is normalized by the maximum intensity at the bead surface. 4 or 5 beads were imaged at each time point, and signal intensities within the particles were quantified. Signal intensity is greatest at the bead surface, and quickly decays as IL-6 diffuses into the bead and adsorbs to the pore walls. Solid lines indicate corresponding nonlinear regression model fits at each time point. (b) Normalized BSA CLSM intraparticle intensity profiles at 2hr, 5.5hr, and 21.5hr incubation times with CytoSorb beads.