Table 2.
Relative gene expression levels in rejecting kidney and heart grafts (relative to control organs)
| Encoded protein1 | Kidney | Heart | Galt-KO kidney |
|---|---|---|---|
| CD31 (PECAM) | +4.1 (±0.8) | → | +3.9 (±0.5) |
| von Willebrand factor (vWf) | +3.5 (±0.4) | +3.4 (±0.8) | +3.7 (±0.6) |
| Superoxide dismutases | +3.6 (±0.8) | → | +3.3 (±0.5) |
| Tissue factor | +3.2 (±0.4) | → | +3.4 (±0.4) |
| Heme oxygenase-1 | +2.1 (±0.2) | → | +2.2 (±0.4) |
| Heat shock protein-72 | +2.1 (±0.4) | → | +2.1 (±0.3) |
| Nitric oxide synthase | +2.1 (±0.33) | → | +2.1 (±0.5) |
| CD39 | +2.0 (±0.2) | +4.1 (±0.5) | +2.1 (±0.2) |
| PAI-1 | → | +3.7 (±0.2) | → |
PAI-1 = plasminogen activator inhibitor-1.
PECAM = platelet endothelial cell adhesion molecules (CD31).
→ = no substantive change in the content of specific mRNA by miniarray.
1
Superoxide dismutases, heme oxygenase-1, CD39 and nitric oxide synthase are potential ‘protective factors’ that are upregulated in response to some stresses. CD39, which is expressed on endothelium, prevents platelet aggregation. CD31/PECAM, vWF, tissue factor and PAI-1 are factors that promote coagulation and thrombosis.