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Transmission electron micrograph of full-length human Tau sample at physiological pH in the presence of 2 mm DTT after incubation for 72 h. The concentration of full-length human Tau protein was 20 μm, and the molar ratio of heparin to Tau was 1:1. A 2% (w/v) uranyl acetate solution was used to negatively stain the fibrils. The scale bar represents 200 nm.
