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. 2009 Dec 29;107(3):1211–1216. doi: 10.1073/pnas.0910302107

Fig. 2.

Fig. 2.

NRG1 inhibition of evoked firing of PFC pyramidal neurons. (A) NRG1 reduced whereas ecto-ErbB4 enhanced action potential frequency of pyramidal neurons in a whole-cell patch-clamping configuration. Representative action potentials are shown of a single neuron before (baseline) and after bath application of vehicle (control), 5 nM NRG1, 5 nM denatured NRG1, or 1 μg/mL ecto-ErbB4, or 20 μM bicuculline and 5 nM NRG1, or 20 μM bicuculline and 1 μg/mL ecto-ErbB4. (B) Quantitative analysis of data in A. n = 9, *P < 0.05, compared with control; #P < 0.05, compared with NRG1. (C) Dose-dependent inhibition of NRG1 on evoked spikes of pyramidal neurons (n = 11).