Skip to main content
. 2009 Dec 28;107(3):1124–1129. doi: 10.1073/pnas.0909333107

Fig. 2.

Fig. 2.

Axl is required for breast cancer cell invasiveness (A and B) Epiallelic MDA-MB-231 cells comprising Axl-targeting shRNA (shAxl2, shAxl280, shAxl278, and shAxl279) and control shRNA (shLuc) show graded Axl surface expression by flow cytometry (A) and total and phosporylated Axl (pAxl) levels by immunoblotting (B). (C) Invasiveness of epiallelic MDA-MB-231 cells is Axl-dependent. *P < .05, (paired t test). (D) Axl is required for invasive, stellate growth of MDA-MB-231 cells in 3D Matrigel (Lower, shAxl2; Upper, shLuc).