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. 2009 Dec 28;107(3):1124–1129. doi: 10.1073/pnas.0909333107

Fig. 5.

Fig. 5.

In vivo epiallelic analysis reveals a distinct Axl expression threshold required for breast tumor formation. (A) Temporal in vivo bioluminescence image analysis of tumor growth (total photon) and radial infiltration (signal diameter) by s.c. Axl epiallelic MDA-MB-231/GFP-Luc xenografts in NOD/SCID mice (n = 6 per group) comprising shAxl278, shAx280, and shAxl2 normalized to shAxl279 (ineffective shRNA). (B) Tumor growth (normalized 28-day total photon measurements) plotted versus Axl knockdown (geometric mean fluorescence) reveal a threshold of 80% reduced surface expression to attain an antitumor effect (therapeutic benefit). *P < .05; **P < .005 (paired t test).