Table 6.
Conj.no. | Immunogen | Dosage, μg | Bleeding after last injection | IgG anti-CSP, EU |
rCSP | 2.5 | 1 week | 99 | |
19 | rCSP-AH-CSP | 2.5 | 1 week | 72 |
20 | NPNA5-C/rCSP | 2.5 | 1 week | 116 |
21 | rCSP/AH-Pfs25 | 5 | 1 week | 39 |
22 | rCSP-AH/Pfs-AH-Pfs | 5 | 1 week | 81 |
22 | rCSP-AH/Pfs-AH-Pfs | 5 | 3 months | 67 |
Mice were injected three times, at 2-week intervals with 2.5 or 5 μg of the immunogen, and bled 1 week or 3 months after the last injection.