Table 7.
Conj. no. | Conjugate | Time of bleeding after the last injection | GM anti-Pfs25, μg/mL | |
Second inj. | Third inj. | |||
23 | Pfs-AH/Pfs | 1 week | 39 | 439 |
23 | Pfs-AH/Pfs | 1 month | 89 | 574 |
23 | Pfs-AH/Pfs | 3 months | 314 | 826 |
23 | Pfs-AH/Pfs | 9 months | 150 | 225 |
23 | Pfs-AH/Pfsalum ads. | 1 week | 239 | – |
23 | Pfs-AH/Pfsalum ads. | 3 months | 1174 | – |
23 | Pfs-AH/Pfsalum ads. | 9 months | 314 | – |
Mice were injected two or three times, at 2-week intervals with 2.5 μg of Pfs25-AH/-Pfs25 conjugate alone or alum adsorbed, and bled at different times after the last injections: 39 vs. 89, P = 0.02, vs. 314, P < 0.001, vs. 150, P = 0.006; 826 vs. 225, P = 0.02; 239 vs. 1174, P < 0.001; 314 vs. 1174, P < 0.001; 39 vs. 239, P < 0.001; 314 vs. 1174, P < 0.001; 150 vs. 314, P = 0.04.