Figure 2. Uteri from Ptenpr−/− and Ptenpr−/−/p53pr−/− show aberrant histology and their loss affects survival.
Histology of A) Ptenpr−/− and B) Ptenpr−/−/p53pr−/− uteri. Hematoxylin and Eosin (H & E) and cytokeratin 8 (CK8) staining of A) Ptenpr−/− and B) Ptenpr−/−/p53pr−/− uteri in mice at various ages (10 days, 3 weeks, 1 month, 2 months and 3 months). C) Effects of endometrial loss of Pten and/or p53 on survival. Wild-type, Ptenpr−/−, p53pr−/− and Ptenpr−/−/p53pr−/− mice were monitored for any sign of sickness for a total of 250 days. We sacrificed mice with any sign of sickness or discomfort and the day of sacrifice was recorded.