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. Author manuscript; available in PMC: 2010 Feb 18.
Published in final edited form as: Cancer Res. 2008 Jul 15;68(14):5619–5627. doi: 10.1158/0008-5472.CAN-08-1274

Figure 4. Cox-2 expression and cell proliferation in Ptenpr−/−/p53pr−/− uteri.

Figure 4

A) Western blot analysis of Cox-2 and Cox-1 in Ptenpr−/−/p53pr−/− uteri. Actin serves as control. B) RT-PCR of Cox-2 in Ptenpr−/−/p53pr−/− uteri. β-Actin is a housekeeping gene. C) In situ hybridization of Cox-2 in Ptenpr−/−/p53pr−/− and wild-type uteri. kid, kidney. Bar, 400 μm. D) Immunohistochemistry of Cox-2 in 3-week old Ptenpr−/−/p53pr−/− and wild-type mice (upper panel). Immunohistochemistry of Ki67 in 3-week and 2 months old Ptenpr−/− and Ptenpr−/−/p53pr−/− and wild-type uteri (lower panels). Arrowheads indicated leading edge. Bar, 200 μm. le, luminal epithelium; ge, glandular epithelium; s, stroma; myo, myometrium; T, tumor.

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