Fig. 1.
Pedigree segregating the A454T mutation and protein location of the amino acid change. (A) Clinical and CACNA1A genetic characterization of a three-generation migraine with aura pedigree. Affected individuals are denoted by solid symbols (squares indicate male family members; circles, female family members; symbols with a slash, members who had died). The type of aura experienced is indicated below. (B) Location of the alanine-to-threonine mutation at position 454 (A454T) in the I-II intracellular loop of the P/Q channel α1A subunit.