Fig. 2.
A454T lessens modulation of P/Q channel activity by CaVβ subunits. Steady-state inactivation was studied with the voltage protocol shown (A). Typical traces obtained from cells expressing WT or A454T P/Q channels including either the β2a (B) or the β3 subunit (C). (D) Steady-state inactivation curves. WTβ2a (○, n = 11); A454Tβ2a (•, n = 14); WTβ3 (△, n = 10), and A454Tβ3 (▲, n = 9). Average kinact for all four channel combinations were between –4.38 and –5.42 mV and did not differ statistically (ANOVA, P = 0.55).