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Overexpression of a βCTF construct induces the AD-like endosomal phenotype in 2N fibroblasts. (A) Western blot of C1/6.1of 2N fibroblasts transfected with pcDNA3:C99-GFP. Immunolabeling with anti-EEA1, N25, and anti-GFP antibodies shows βCTF (B) and EEA1 (C) in transfected and nontransfected (arrowhead) 2N fibroblasts. (D) Relative numbers of endosomes in transfected and nontransfected 2N fibroblasts (mean ± SEM, n = 55). **, P < 0.01; ***, P < 0.001.
