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Altered early endosomal morphology in DS fibroblasts transfected with pSilencer: BACE-1. Immunolabeling showed EEA1-positive vesicle in pSilencer- (A) and shBACE1- (B) transfected DS fibroblasts, with cotransfection of pGFP as a marker for transfection. The contrast levels have been adjusted in B. (C) Sizes of EEA1-positive vesicles in vector and shBACE1-transfected fibroblasts were calculated and graphed (mean ± SEM, n = 52). ***, P < 0.001.
