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Schematic of the transmembrane glycoprotein gp41. The MPER comprises the continuous epitopes of three broadly neutralizing monoclonal antibodies: 2F5 (ELDKWA), 4E10 (NWFDIT), and Z13e1 (WASLWNWFDITN). The enlarged residues indicate essential determinants of neutralization as described in the text. FP, fusion peptide; TM, transmembrane domain; CT, cytoplasmic tail.
