Fig. 1.

Role of LGP2 in type I IFN production in response to various RNA viruses. (A and B) BM-derived cDCs from WT and Lgp2 ^−/− mice were exposed to the indicated viruses or treated with 1 μM CpG-DNA (D35) for 24 h. The concentrations of IFN-β (A) and IL-6 (B) in the culture supernatants were measured by ELISA. moi, multiplicity of infection; med, medium alone. Data are shown as means ± SD and are representative of at least three independent experiments.