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(A) Spleens from 6-week-old mice with indicated genotype. (B) Organ weights plotted as per cent of total body weight (n=4). (C) Red blood cell indices of wild-type (+/+, n=15), heterozygous (+/ki, n=11) and homozygous mutant (ki/ki, n=10) animals. Error bars represent s.e.m. P-values were determined by two-tailed t-tests. *P<0.001. (D) Giemsa—Wright-stained peripheral blood smears from +/+ and ki/ki mice. Note scarcity of normal sized platelets and the presence of enlarged platelets.
