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(A) Platelet counts of wild-type (+/+, n=15), heterozygous (+/ki, n=11) and homozygous mutant (ki/ki, n=10) animals. Error bars represent s.e.m. *P<0.001; **P<0.05. (B) Electron micrographs of +/+ and ki/ki platelets. (C) Reduced MK potential in ki/ki mice as revealed by colony assays from bone marrows. ki/ki bone marrows produced markedly fewer CFU-Mk colonies in but increased numbers of single MKs. Right panel: acetyl-cholinesterase (AChE) stain of representative colonies.
