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. 2009 Nov 26;29(2):482–495. doi: 10.1038/emboj.2009.344

Figure 7.

Figure 7

Peptides that disrupt the β2AR–AMPAR interaction specifically prevent the ISO-induced increase in EPSCs amplitude in PFC slices. (A–C) Basal AMPAR-EPSC amplitudes were significantly reduced by injection of the DSPL peptide (50 μM) by 25.2±4.9% (n=5), but not by the control DAPA peptide (50 μM; 3.2±2.2% reduction; n=5). DSPL diminished the ISO response to an increase of 15.7±5.9% (n=7), but DAPA did not cause any significant reduction (increase was 54.3±6.6%; n=6). (D–F) Basal AMPAR-EPSC amplitudes were significantly reduced by injection of the ESDV peptide (50 μM) by 37.5±4% (n=10), but not by the control EADA peptide (50 μM; 8.8±4.7% reduction; n=10). ESDV diminished the ISO response to an increase of 6.8±2.7% (n=10), but DAPA did not cause any significant reduction (increase was 62.7±12.9%; n=10).